House dust mite–driven asthma and allergen-specific T cells depend on B cells when the amount of inhaled allergen is limiting
M Dullaers, MJ Schuijs, M Willart, K Fierens… - Journal of Allergy and …, 2017 - Elsevier
Background Allergic asthma is a CD4 TH 2-lymphocyte driven disease characterized by
airway hyperresponsiveness and eosinophilia. B cells can present antigens to CD4 T cells
and produce IgE immunoglobulins that arm effector cells; however, mouse models are
inconclusive on whether B cells are necessary for asthma development. Objectives We
sought to address the role of B cells in a house dust mite (HDM)–driven TH 2-high asthma
mouse model. Methods Wild-type and B cell–deficient muMT mice were sensitized and …
airway hyperresponsiveness and eosinophilia. B cells can present antigens to CD4 T cells
and produce IgE immunoglobulins that arm effector cells; however, mouse models are
inconclusive on whether B cells are necessary for asthma development. Objectives We
sought to address the role of B cells in a house dust mite (HDM)–driven TH 2-high asthma
mouse model. Methods Wild-type and B cell–deficient muMT mice were sensitized and …
